Endocrine Abstracts

The Liver X Receptors (LXRs) are members of the nuclear hormone receptor superfamily and play a key role as intracellular cholesterol sensors. LXRs control the expression of crucial genes associated with cholesterol absorption, excretion and efflux and are therefore key determinants of atherosclerosis susceptibility. In addition, recent studies have revealed the existence of crosstalk between macrophage inflammatory pathways and LXR signaling. In activated macrophages, LXR ago...